Phosphine-Catalyzed [3+2] Cycloadditions
of 2-Phenyl-4-Arylidene-5(4H)-Oxazolones
with Allenoate: A Concise Synthesis of Aspartic Acid Analogues

You-Quan Zou; Chao Li; Jian Rong; Hao Yan; Jia-Rong Chen; Wen-Jing Xiao

doi:10.1055/s-0030-1259709

LETTER

Phosphine-Catalyzed [3+2] Cycloadditions of 2-Phenyl-4-Arylidene-5(4H)-Oxazolones with Allenoate: A Concise Synthesis of Aspartic Acid Analogues

You-Quan Zou, Chao Li, Jian Rong, Hao Yan, Jia-Rong Chen*, Wen-Jing Xiao*
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, P. R. of China
Fax: +86(27)67862041; e-Mail: wxiao@mail.ccnu.edu.cn;

Abstract

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Abstract

A Ph₃P-catalyzed [3+2] cycloaddition of 2-phenyl-4-arylidene-5(4H)-oxazolones with benzyl 2,3-butadienoate has been developed for the efficient synthesis of structurally diverse and conformationally constrained aspartic acid analogues.

Key words

cycloaddition - organocatalysis - phosphine - benzyl 2,3-butadienoate - aspartic acid analogues

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References

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Supplementary Material

Supporting Information